IPOscore ‒ Predicting the risk of complications of surgical treatment and define prognosis of cancer patients through the integration of clinical and biopathological data
This project intends to apply an innovative approach based on data-driven modeling that integrates clinical, biopathological and physiological data of patients with cancer to predict the risk of (post-)operative complications. The expected outcome is the creation of an user-friendly online platform, which includes a database to store/manage the data collected in a structured format, computational approaches and prediction models to calculate a specific risk index score for the Portuguese population. The platform will provide an added-value to surgeons in oncological hospitals as an intelligent clinical decision support system.
[J1] A. Fernandes, J. Rodrigues, P. Lages, S. L. P. Mendes, L. Antunes, C. S. Santos, C. Castro, R. S. Costa, C. S. Lopes, P. Costa, L. L. Santos. Root causes and outcomes of postoperative pulmonary complications after abdominal surgery: a retrospective observational cohort study. Patient Safety in Surgery, 13, 40 (2019) | (doi: 10.1186/s13037-019-0221-5)
[J2] E. Fernandes, D. Ferreira, A. Peixoto, R. Freitas, M. Relvas-Santos, C. Palmeira, G. Martins, A. Barros, L. L. Santos, B. Sarmento, J. A. Ferreira. Glycoengineered nanoparticles enhance the delivery of 5-fluoroucil and paclitaxel to gastric cancer cells of high metastatic potential. International Journal of Pharmaceutics, 570, 118646 (2019) | (doi: 10.1016/j.ijpharm.2019.118646)
[J3] E. Fernandes, J. Sores, S. Cotton, A. Peixoto, D. Ferreira, R. Freitas, C. A. Reis, L. L. Santos and J. A. Ferreira. Esophageal, gastric and colorectal cancers: Looking beyond classical serological biomarkers towards glycoproteomics-assisted precision oncology. Theranostics (2020) | (doi:10.7150/thno.42480)
[J4] A. Fernandes, J. Rodrigues, L. Antunes, P. Lages, C. S. Santos, D. Moreira-Gonçalves, R. S. Costa, J. A. Sousa, M. Dinis-Ribeiro, L. L. Santos. Development of a preoperative risk score for predicting postoperative complication in gastrointestinal cancer surgery. Perioperative Medicine (2020) |
[J5] A. S. Menezes, A. Fernandes, J. R. Rodrigues, C. Salomé, F. Machado, L. Antunes, J. C. Silva, E. Monteiro, L. L. Santos. Optimizing classical risk scores to predict complications in head and neck surgery: a new approach. European Archives of Oto-Rhino-Laryngology (2020) | (doi: https://doi.org/10.1007/s00405-020-06133-1)