IPOscore ‒ Predicting the risk of complications of surgical treatment and define prognosis of cancer patients through the integration of clinical and biopathological data

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This project intends to apply an innovative approach based on data-driven modeling that integrates clinical, biopathological and physiological data of patients with cancer to predict the risk of (post-)operative complications. The expected outcome is the creation of an user-friendly online platform, which includes a database to store/manage the data collected in a structured format, computational approaches and prediction models to calculate a specific risk index score for the Portuguese population. The platform will provide an added-value to surgeons in oncological hospitals as an intelligent clinical decision support system.


[J1] A. Fernandes, J. Rodrigues, P. Lages, S. L. P. Mendes, L. Antunes, C. S. Santos, C. Castro, R. S. Costa, C. S. Lopes, P. Costa, L. L. Santos. Root causes and outcomes of postoperative pulmonary complications after abdominal surgery: a retrospective observational cohort study. Patient Safety in Surgery, 13, 40 (2019) | (doi: 10.1186/s13037-019-0221-5)

[J2] E. Fernandes, D. Ferreira, A. Peixoto, R. Freitas, M. Relvas-Santos, C. Palmeira, G. Martins, A. Barros, L. L. Santos, B. Sarmento, J. A. Ferreira. Glycoengineered nanoparticles enhance the delivery of 5-fluoroucil and paclitaxel to gastric cancer cells of high metastatic potential. International Journal of Pharmaceutics, 570, 118646 (2019) | (doi: 10.1016/j.ijpharm.2019.118646)

[J3] E. Fernandes, J. Sores, S. Cotton, A. Peixoto, D. Ferreira, R. Freitas, C. A. Reis, L. L. Santos and J. A. Ferreira. Esophageal, gastric and colorectal cancers: Looking beyond classical serological biomarkers towards glycoproteomics-assisted precision oncology. Theranostics (2020) | (doi:10.7150/thno.42480)

[J4] A. Fernandes, J. Rodrigues, L. Antunes, P. Lages, C. S. Santos, D. Moreira-Gonçalves, R. S. Costa, J. A. Sousa, M. Dinis-Ribeiro, L. L. Santos. Development of a preoperative risk score for predicting postoperative complication in gastrointestinal cancer surgery. Perioperative Medicine (2020) |

[J5] A. S. Menezes, A. Fernandes, J. R. Rodrigues, C. Salomé, F. Machado, L. Antunes, J. C. Silva, E. Monteiro, L. L. Santos. Optimizing classical risk scores to predict complications in head and neck surgery: a new approach. European Archives of Oto-Rhino-Laryngology (2020) | (doi: https://doi.org/10.1007/s00405-020-06133-1)